Achievement of aesthetic restorations that resemble natural teeth represent a great challenge for both dentists and technicians. Obtaining optimal results with the minimum number of try-in tests or repetitions necessarily implies performing a systematic and exhaustive shade analysis. Advanced photographic techniques need to be used for this task, including different kinds of illumination and precise calibration of RAW files. Defining proper shade selection strategies for both composites and ceramics is of paramount importance for our daily work. The Bio-Emulation approach provides specific tools designed to increase dramatically the accuracy of our shade matching, including the custom_eyes shade tabs as well as the “state of the art” eLAB protocol. Ultimately, a successful treatment will always be the outcome of a good communication with patient and perfect teamwork between dentist and technician.