Clinical management of calcified teeth provide an endodontic treatment challenge and makes up a significant portion of current endodontic practice. The people are living longer and want to mantain their natural dentition. There are several factors that might influence the development of varying degrees of moderate and severe calcification of the pulp chamber as well as the root canal system, like, multiple restorations, trauma, vital pulp therapy and chronic irritation from deep restorations or cracks. Pulp canal obliteration, also called calcific metamorphosis, is a sequelae of tooth trauma, and it’s generally asymptomatic and clinically the patients present to the practitioner with yellow discoloration of the affected tooth crown and apparent loss of the pulp space radiographically. The critical management decision is: when to treat these teeth endodontically ? The difficulty degree of the clinical management of this kind of cases, the practicioner should be aware of the possible complications, that may occur. This lecture tries to give some tips to help the clinician to deal with this clinical challenge.